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Inhibitory effects of compounds 1–9 on NO and PGE2 production.
| Compound | NO Production Inhibitory Effects in BV2 Microglial Cells (IC50 = μM) | PGE2 Production Inhibitory Effects in BV2 Microglial Cells (IC50 = μM) |
|---|---|---|
| 1 | n.d. | n.d. |
| 2 | n.d. | n.d. |
| 3 | 40.2 ± 2.0 * | 35.8 ± 1.8 * |
| 4 | 55.3 ± 2.8 * | 56.2 ± 2.8 * |
| 5 | n.d. | n.d. |
| 6 | n.d. | n.d. |
| 7 | n.d. | n.d. |
| 8 | 9.3 ± 0.5 * | 13.5 ± 0.7 * |
| 9 | 70.9 ± 3.5 * | 76.7 ± 3.8 * |
Each value represents the mean ± SD (n = 3). * p < 0.001, compared with the LPS group.
