Table 2.
Pathological changes in the liver and Ridit analysis.
| Groups | Dosage (mg/kg) | n | Necrocytosis Grade | Score | Ridit Analysis | ||||
|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | |||||
| Normal | — | 8 | 8 | 0 | 0 | 0 | 0 | 0 | 0.28 |
| CCl4 | — | 8 | 0 | 2 | 3 | 3 | 0 | 17 | 0.84 * |
| Maltol | 100 | 8 | 7 | 1 | 0 | 0 | 0 | 1 | 0.33 |
| CCl4 + Maltol | 100 | 8 | 3 | 4 | 1 | 0 | 0 | 6 | 0.55 # |
Note: We used H & E staining to evaluate the degree of hepatocyte necrosis, and they were classified according to the following rulers. Ridit analysis was used to analyze the date. Values represent the mean ± S.D., n = 8. * p < 0.05 vs. normal group; # p < 0.05 vs. CCl4 group. Grading standards can be divided into level 0, level 1, level 2, level 3 and level 4, which illustrate no necrocytosis, normal in the liver cells; cells containing necrocytosis of no more than 1/4; cells containing necrocytosis of no more than 1/2; cells containing necrocytosis of no more than 3/4; and almost all cells containing necrocytosis, respectively. Level 0 scored 0 mark, Level 1 scored 1 mark, Level 2 scored 2 marks, Level 3 scored 3 marks, Level 4 scored 4 marks.