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. 2018 Aug 25;23(9):2142. doi: 10.3390/molecules23092142

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Hydrophobicity plots for hIAPP (red), r-IAPP (green), and a triple mutated version of hIAPP with substitutions at H18R, G14P, and I26P, which is non-toxic (TM-IAPP) (purple), and I26P-IAPP (blue), which is a substitution in hIAPP that is known to change aggregation propensity. Panel (A) describes the full sequence of IAPP, while panel (B) shows the key region of interest (residues 16 to 32). The vertical axis is residue solvation free energy as calculated from an octanol-to-water partition scale with mole-fraction units with glycine set to zero. Larger positive values indicate increased hydrophobicity. Adapted from Abedini et al. [22]. Licensed under a Creative Commons Attribution (CC BY) license.