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. 2018 Sep 13;23(9):2341. doi: 10.3390/molecules23092341

Figure 2.

Figure 2

Relative enrichment or depletion of individual amino acids in 77 quadruplex binding proteins versus (A) 5000 randomly subsampled human proteins from UNIPROT database, (B) 15,224 nucleic acid binding proteins including isoforms from Ensembl Biomart, (C) 2565 Golgi apparatus proteins including isoforms from Ensembl Biomart. The analyses were performed using Composition Profiler (10,000 bootstrap iterations with Bonferroni correction for testing multiple hypotheses). Using Bonferroni correction, only values lower than 0.0025 were taken as significant (* p < 0.0025; ** p < 0.0010; *** p < 0.0001). p-values are shown in Supplementary material S13. (D) Correlation diagram of amino acid content in quadruplex binding proteins. Non-significant correlations (p-values > 0.05) are crossed out.