Scheme 5.
Reagents and conditions: (viii) K3PO4·H2O, Cu0, CuI, 90 °C, 5 h, 51%; (ix) Propargyl bromide, NaOH, toluene, TBA HSO4, rt, 5 h, 84%; (x) Benzene, 1-butanol, 100 °C, 2 h, 92%; (xi) TBTACu(I)Br, DIPEA, CHCl3, rt, sonication, 4 h, 42%.
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