Table 1.

Binding Energy of trans-4-hydroxystilbene (THS), resveratrol (RES), and piceatannol (PIC) and Akt protein docking systems.

Stilbenoids	Binding Energy (Kcal/mol)	Ki (μM)	Final Intermolecular Energy (Kcal/mol)	VDW + H Bond + Desolvation Energy (Kcal/mol)	H Bonds
trans-4-hydroxystilbene	−6.31 ± 0.33	23.78	−7.2	−7.1	THS:O1H1-GLU432:O
					ASN231:ND2-THS:O1
resveratrol	−6.69 ± 0.68	12.54	−8.18	−7.82	RES:O1-LEU213:O
					RES:O2-TYR229:O
					LYS284:NZ-RES:O2
					TYR175:HN-RES:O3
piceatannol	−6.73 ± 0.51	11.75	−8.52	−8.28	PIC:HAD-ILE447:O
					PIC:H1-ILE447:O
					PIC:H2-PRO451:O
					PIC:H3-PHE150:O
					PIC:H3-MET147:O