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. 2018 Aug 21;23(9):2100. doi: 10.3390/molecules23092100

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Non-invasive MRI of EndoC-βH1 xenograft bearing-mice using Gd-DOTA-P88 and Gd-DOTA-Scramble. (A–D) Representative MR images of mice bearing EndoC-βH1 transplants. Pre-contrast images (A,C) were acquired before injection of CAs and the post-contrast images were obtained 50 min (B,D) after i.v. administration of 0.1 mmoL Gd/kg b.w. of Gd-DOTA-P88 (B) or Gd-DOTA-Scramble (D). Mice were implanted with EndoC-βH1 grafts in transplantation rings in the right hind leg and vehicle transplantation rings in the left hind leg. The images are displayed in grey-scale (left row) and in pseudo-coloring overlay (right row). The images are representative of 4–6 similar experiments. Legend: SC = spinal cord; EXG = EndoC-βH1 xenograft; L = left; R = right.