Table 3.

Precision and accuracy of analytes at LLOQ and QC samples in beagle dog plasma (n = 6).

Analytes	Spiked Concentration (ng/mL)	Mean ± SD (ng/mL)	Intra-day Precision RSD (%)	Inter-day Precision RSD (%)	Accuracy RE (%)
aesculin	0.50	0.56 ± 0.15	10.7	6.9	16.5
	1.52	1.54 ± 0.22	4.1	8.4	1.6
	12.18	12.42 ± 2.16	9.5	6.2	2.8
	78.00	74.11 ± 6.30	5.9	4.6	6.8
aesculetin	1.09	1.12 ± 0.15	11.9	14.2	5.1
	3.27	14.02 ± 1.57	6.0	7.4	2.4
	26.16	24.31 ± 2.23	8.9	9.1	−4.9
	167.3	172.3 ± 18.35	3.5	8.9	5.4
fraxetin	2.15	2.08 ± 0.22	15.2	7.7	−1.8
	6.45	6.34 ± 0.36	4.5	3.3	−1.5
	51.60	53.53 ± 2.31	6.4	7.2	3.7
	330.2	347.9 ± 18.46	9.3	7.9	5.4
fraxin	1.25	1.20 ± 0.11	10.5	16.1	−3.4
	3.76	3.44 ± 0.36	5.8	3.9	−5.2
	30.12	32.90 ± 2.74	7.0	5.6	5.9
	192.8	186.3 ± 11.06	5.8	7.3	3.3
polydatin	0.50	1.23 ± 0.13	6.2	15.6	13.1
	1.52	1.55 ± 0.39	9.5	11.6	8.3
	12.18	13.87 ± 2.67	6.9	5.8	6.4
	78.00	75.1 ± 13.39	4.3	7.7	4.8