Table 6.
Pharmocokinetic parameters of five analytes in beagle dog plasma after oral administration of the extract of Ledum palustre L.
| Analytes | Cmax (ng/mL) | Tmax (h) | T1/2 (h) | AUC0→t (ng/h/L) | AUC0→∞ (ng/h/L) |
|---|---|---|---|---|---|
| aesculin | 46.75 ± 7.46 | 1.32 ± 0.38 | 3.43 ± 0.47 | 258.5 ± 20.45 | 342.4 ± 35.82 |
| aesculetin | 209.9 ± 27.65 | 1.03 ± 0.27 | 4.25 ± 0.18 | 314.3 ± 30.92 | 355.9 ± 30.52 |
| fraxetin | 369.7 ± 48.87 | 0.94 ± 0.23 | 3.76 ± 0.35 | 940.1 ± 52.89 | 992.8 ± 46.96 |
| fraxin | 67.04 ± 12.09 | 0.89 ± 0.18 | 2.99 ± 0.29 | 147.2 ± 21.74 | 191.5 ± 22.18 |
| polydatin | 47.14 ± 12.04 | 1.15 ± 0.15 | 3.36 ± 0.31 | 89.82 ± 14.04 | 98.28 ± 12.11 |