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. 2018 Aug 23;23(9):2116. doi: 10.3390/molecules23092116

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme 2 — Synthetic route for compounds 4a–4x and 8a–8n. (A) Reagents and conditions for 4a–4x: (a) absolute ethanol, hydrazine hydrate, refluxing for 90 min; (b) absolute ethanol, 2-furoylacetonitrile, refluxing for 120 min; (c) anhydrous DCM, substituted acyl chloride, Et₃N, room temperature, overnight. (B) Reagents and conditions for 8a–8n: (a) absolute ethanol, hydrazine hydrate, refluxing for 180 min; (b) absolute ethanol, 2-furoylacetonitrile, refluxing for 180 min; (c) anhydrous DCM, substituted acyl chloride, Et₃N, room temperature, overnight.