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. 2018 Oct 27;140(44):14945–14951. doi: 10.1021/jacs.8b09320

Figure 1.

Figure 1

(A–C) Schematic illustrations of the three isomeric peptide–H2S donor conjugates (PHDCs) in this study. (D–F) Cryo-TEM characterization illustrates the effect of sequence on the self-assembled morphology of constitutionally isomeric PHDCs: (D) cryo-TEM image of twisted ribbons formed by KSEKSE in aqueous solution, (E) cryo-TEM image of twisted ribbons formed by KSKSEE in aqueous solution, and (F) cryo-TEM image of nanocoils formed by KSEEKS in aqueous solution. (G) AFM phase image of nanocoils formed by KSEEKS in aqueous solution. Solution concentration: 1 mM PHDCs in PBS (pH 7.4). (H) SAXS curve of KSEEKS in aqueous solution (1 mM in PBS at pH 7.4) with fitting to a helical model. (I–K) Circular dichroism spectra of (I) KSEKSE, (J) KSKSEE, and (K) KSEEKS in phosphate buffer (pH 7.4) at a concentration of 100 μM.