Scheme 1.
Synthesis of compounds 5a–5o. Reagents and conditions: (a) Propargyl bromide, K2CO3, DMF, r.t., 4 h; (b) NaNO2, HCl, 0.5 h, NaN3, 0.5 h; (c) CuI, Et3N, DCM, r.t., 3 h; (d) SOCl2, 1.5 h; (e) RNH2, DCM, 2 h.
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