Table 2.

The effect of inhibitors of the renin-angiotensin system on clinical data including body weight (BW), albumin concentration, urinary albumin excretion rate (UAER), and renin plasma concentration data are shown as mean ± SD.

Groups	Vehicle	Healthy ctrls	Enalapril	Enalapril	Losartan	Losartan
	N = 10	N = 10	15mg/kg N = 10	30mg/kg N = 10	15mg/kg N = 10	30mg/kg N = 10
Bodyweight (g)	Start	Start	Start	Start	Start	Start
	31.2 ± 2.4	31.3 ± 1.8	31.3 ± 2.3	30.8 ± 1.4	30.2 ± 1.4	31.3 ± 0.9
	End	End	End	End	End	End
	33.1 ± 2.7	34.3 ± 2.9	33.5 ± 2.6	32.5 ± 2.2	32.9 ± 1.7	33.7 ± 1.7
Albumin (mg/ml)	Day 7–8	Day 7–8****	Day 7–8***	Day 7–8****	Day 7–8*	Day 7–8****
	30.3 ± 10.4	0.04 ± 0.03	11.8 ± 8.8	8.9 ± 8.8	18.2 ± 9.8	9.9 ± 5.5
	Day 36–37	Day 36–37****	Day 36–37****	Day 36–37****	Day 36–37	Day 36–37****
	6.6 ± 3.6	0.02 ± 0.02	1.1 ± 1.0	1.0 ± 1.4	3.9 ± 3.4	0.8 ± 0.6
Urinary albumin excretion rate (mg/24hrs)	Day 7–8	Day 7–8****	Day 7–8****	Day 7–8****	Day 7–8**	Day 7–8****
	75.0 ± 28.6	0.04 ± 0.02	19.9 ± 18.1	12.6 ± 15.3	38.0 ± 22.7	19.1 ± 15.0
	Day 36–37	Day 36–37****	Day 36–37****	Day 36–37****	Day 36–37***	Day 36–37****
	23.1 ± 16.4	0.04 ± 0.04	2.1 ± 1.8	1.0 ± 11.4	6.4 ± 7.9	1.8 ± 2.9
Albumin creatinine ratio (mg/mmol)	Day 36–37	Day 36–37***		Day 36-37***		Day 36–37***
	4437 ± 2797	320.1 ± 120.3		312.3 ± 469.5		544.6 ± 302.2
Renin (pg/ml)	Day 13	Day 13	Day 13****	Day 13****	Day 13	Day 13*
	23296 ± 6579	15793 ± 3132	59849 ± 14187	62956 ± 20631	42021 ± 11893	43144 ± 9421
	Day 42	Day 42	Day 42****	Day 42****	Day 42	Day 42
	20972 ± 9578	19283 ± 47686	217021 ± 55210	297891 ± 130809	73480 ± 77856	114541 ± 72979