Table A1.
Pairwise comparisons between (i) saliva/plaque samples collected from groups A and B after the initial four-week ‘washout period’ (i.e. A1s vs B1s; A1p vs B1p), (ii) saliva/plaque from each group before and after treatment with either xylitol (A1s vs A1Xs; A1p vs A1Xp; B2s vs B2Xs; B2p vs B2Xp) or sorbitol (A2s vs A2Ss; A2p vs A2Sp; B1s vs B1Ss; B1p vs B1Sp) and (iii) between samples collected from each group at the start of their treatment 1 versus at the start of their treatment 2 (A1s vs A2s; A1p vs A2p; B1s vs B2s; B1p vs B2p).
| PLAQUE | ||||
|---|---|---|---|---|
| Taxonomy | Site | Name | P value | Adjusted p value |
| Actinobacteria;Actinomyces_massiliensis | Plaque | A1p-A1Xp | 0.328666786 | 0.555333536 |
| Actinobacteria;Actinomyces_sp._oral_taxon_849 | Plaque | A1p-A1Xp | 0.049735521 | 0.149189705 |
| Actinobacteria;Actinomyces_urogenitalis | Plaque | A1p-A1Xp | 0.14774294 | 0.297219779 |
| Actinobacteria;Actinomyces_viscosus | Plaque | A1p-A1Xp | 0.149881296 | 0.297219779 |
| Bacteroidetes;Alloprevotella_rava | Plaque | A1p-A1Xp | 0.151642744 | 0.297219779 |
| Proteobacteria;Rhodanobacter_sp._115 | Plaque | A1p-A1Xp | 0.193578818 | 0.351309706 |
| Saccharibacteria;TM7 | Plaque | A1p-A1Xp | 0.113104665 | 0.251914936 |
| Actinobacteria;Actinomyces_massiliensis | Plaque | A1p-A2p | 6.61E-04 | 0.005399577 |
| Actinobacteria;Actinomyces_sp._oral_taxon_849 | Plaque | A1p-A2p | 3.30E-04 | 0.004044186 |
| Actinobacteria;Actinomyces_urogenitalis | Plaque | A1p-A2p | 2.11E-05 | 3.45E-04 |
| Actinobacteria;Actinomyces_viscosus | Plaque | A1p-A2p | 4.19E-04 | 0.004105014 |
| Bacteroidetes;Alloprevotella_rava | Plaque | A1p-A2p | 0.647566221 | 0.926028653 |
| Proteobacteria;Rhodanobacter_sp._115 | Plaque | A1p-A2p | 1.12E-05 | 2.74E-04 |
| Saccharibacteria;TM7 | Plaque | A1p-A2p | 0.05307183 | 0.149189705 |
| Actinobacteria;Actinomyces_massiliensis | Plaque | A1p-B1p | 0.045874973 | 0.149189705 |
| Actinobacteria;Actinomyces_sp._oral_taxon_849 | Plaque | A1p-B1p | 0.093215724 | 0.217503357 |
| Actinobacteria;Actinomyces_urogenitalis | Plaque | A1p-B1p | 0.7471924 | 0.926028653 |
| Actinobacteria;Actinomyces_viscosus | Plaque | A1p-B1p | 0.04110205 | 0.143857174 |
| Bacteroidetes;Alloprevotella_rava | Plaque | A1p-B1p | 0.00850493 | 0.04630462 |
| Proteobacteria;Rhodanobacter_sp._115 | Plaque | A1p-B1p | 0.759952871 | 0.926028653 |
| Saccharibacteria;TM7 | Plaque | A1p-B1p | 0.7959974 | 0.928663633 |
| Actinobacteria;Actinomyces_massiliensis | Plaque | A2p-A2Sp | 0.756376762 | 0.926028653 |
| Actinobacteria;Actinomyces_sp._oral_taxon_849 | Plaque | A2p-A2Sp | 0.905062742 | 1 |
| Actinobacteria;Actinomyces_urogenitalis | Plaque | A2p-A2Sp | 0.092342593 | 0.217503357 |
| Actinobacteria;Actinomyces_viscosus | Plaque | A2p-A2Sp | 0.720314184 | 0.926028653 |
| Bacteroidetes;Alloprevotella_rava | Plaque | A2p-A2Sp | 0.979958253 | 1 |
| Proteobacteria;Rhodanobacter_sp._115 | Plaque | A2p-A2Sp | 1 | 1 |
| Saccharibacteria;TM7 | Plaque | A2p-A2Sp | 0.325503952 | 0.555333536 |
| Actinobacteria;Actinomyces_massiliensis | Plaque | B1p-B1Sp | 0.774840302 | 0.926028653 |
| Actinobacteria;Actinomyces_sp._oral_taxon_849 | Plaque | B1p-B1Sp | 0.743702065 | 0.926028653 |
| Actinobacteria;Actinomyces_urogenitalis | Plaque | B1p-B1Sp | 0.682673808 | 0.926028653 |
| Actinobacteria;Actinomyces_viscosus | Plaque | B1p-B1Sp | 0.9348872 | 1 |
| Bacteroidetes;Alloprevotella_rava | Plaque | B1p-B1Sp | 0.35064789 | 0.572724887 |
| Proteobacteria;Rhodanobacter_sp._115 | Plaque | B1p-B1Sp | 0.45429626 | 0.718081184 |
| Saccharibacteria;TM7 | Plaque | B1p-B1Sp | 0.054804382 | 0.149189705 |
| Actinobacteria;Actinomyces_massiliensis | Plaque | B1p-B2p | 0.016431722 | 0.067096199 |
| Actinobacteria;Actinomyces_sp._oral_taxon_849 | Plaque | B1p-B2p | 0.016431722 | 0.067096199 |
| Actinobacteria;Actinomyces_urogenitalis | Plaque | B1p-B2p | 9.01E-04 | 0.00630748 |
| Actinobacteria;Actinomyces_viscosus | Plaque | B1p-B2p | 0.011256008 | 0.055154438 |
| Bacteroidetes;Alloprevotella_rava | Plaque | B1p-B2p | 0.006701628 | 0.041047469 |
| Proteobacteria;Rhodanobacter_sp._115 | Plaque | B1p-B2p | 2.54E-06 | 1.24E-04 |
| Saccharibacteria;TM7 | Plaque | B1p-B2p | 0.023761631 | 0.089563071 |
| Actinobacteria;Actinomyces_massiliensis | Plaque | B2p-B2Xp | 0.967417298 | 1 |
| Actinobacteria;Actinomyces_sp._oral_taxon_849 | Plaque | B2p-B2Xp | 0.512486352 | 0.784744727 |
| Actinobacteria;Actinomyces_urogenitalis | Plaque | B2p-B2Xp | 0.90075159 | 1 |
| Actinobacteria;Actinomyces_viscosus | Plaque | B2p-B2Xp | 0.53929854 | 0.800776619 |
| Bacteroidetes;Alloprevotella_rava | Plaque | B2p-B2Xp | 0.163829361 | 0.308755335 |
| Proteobacteria;Rhodanobacter_sp._115 | Plaque | B2p-B2Xp | 1 | 1 |
| Saccharibacteria;TM7 | Plaque | B2p-B2Xp | 0.066010552 | 0.17023774 |
| SALIVA | ||||
| Actinobacteria;Actinomyces_sp._oral_taxon_849 | Saliva | A1s-A1Xs | 0.245630188 | 0.568153304 |
| Actinobacteria;Actinomyces_urogenitalis | Saliva | A1s-A1Xs | 0.07890077 | 0.275414312 |
| Actinobacteria;Rothia_mucilaginosa | Saliva | A1s-A1Xs | 0.602685023 | 0.871272914 |
| Bacteroidetes;Prevotella_maculosa | Saliva | A1s-A1Xs | 0.623379069 | 0.882015066 |
| Bacteroidetes;Prevotella_oris | Saliva | A1s-A1Xs | 0.73445985 | 0.957678039 |
| Firmicutes;Dialister_invisus | Saliva | A1s-A1Xs | 0.112724945 | 0.339014806 |
| Firmicutes;Dialister_succinatiphilus | Saliva | A1s-A1Xs | 0.977018424 | 1 |
| Firmicutes;Enterococcus_italicus | Saliva | A1s-A1Xs | 0.70061057 | 0.950828631 |
| Firmicutes;Gemella_sanguinis | Saliva | A1s-A1Xs | 0.73445985 | 0.957678039 |
| Firmicutes;Granulicatella_adiacens | Saliva | A1s-A1Xs | 0.137068495 | 0.368285048 |
| Firmicutes;Oribacterium_sinus | Saliva | A1s-A1Xs | 0.70061057 | 0.950828631 |
| Firmicutes;Oribacterium_sp._ACB7 | Saliva | A1s-A1Xs | 0.910025875 | 1 |
| Firmicutes;Selenomonas_sp._oral_taxon_149 | Saliva | A1s-A1Xs | 0.945022036 | 1 |
| Firmicutes;Selenomonas_sputigena | Saliva | A1s-A1Xs | 0.981456799 | 1 |
| Firmicutes;Streptococcus_cristatus | Saliva | A1s-A1Xs | 0.803612769 | 0.988409148 |
| Firmicutes;Streptococcus_intermedius | Saliva | A1s-A1Xs | 0.039481661 | 0.172165931 |
| Firmicutes;Streptococcus_peroris | Saliva | A1s-A1Xs | 0.482400752 | 0.787230675 |
| Firmicutes;Streptococcus_porcinus | Saliva | A1s-A1Xs | 0.115547329 | 0.339014806 |
| Firmicutes;Streptococcus_pseudoporcinus | Saliva | A1s-A1Xs | 0.033518456 | 0.153722573 |
| Firmicutes;Streptococcus_sp._oral_taxon_056 | Saliva | A1s-A1Xs | 0.049735521 | 0.200449221 |
| Firmicutes;Streptococcus_sp._SK643 | Saliva | A1s-A1Xs | 0.137068495 | 0.368285048 |
| Firmicutes;Streptococcus_suis | Saliva | A1s-A1Xs | 0.334528112 | 0.649521736 |
| Firmicutes;Streptococcus_thermophilus | Saliva | A1s-A1Xs | 0.320885138 | 0.644299985 |
| Firmicutes;Streptococcus_vestibularis | Saliva | A1s-A1Xs | 0.328666786 | 0.644299985 |
| Firmicutes;Veillonella_sp._oral_taxon_780 | Saliva | A1s-A1Xs | 1 | 1 |
| Proteobacteria;Aggregatibacter_segnis | Saliva | A1s-A1Xs | 0.581326862 | 0.859071918 |
| Proteobacteria;Campylobacter_concisus | Saliva | A1s-A1Xs | 0.981668632 | 1 |
| Proteobacteria;Campylobacter_gracilis | Saliva | A1s-A1Xs | 0.806043377 | 0.988409148 |
| Proteobacteria;Campylobacter_showae | Saliva | A1s-A1Xs | 0.363627882 | 0.676841283 |
| Proteobacteria;Haemophilus_parainfluenzae | Saliva | A1s-A1Xs | 0.602685023 | 0.871272914 |
| Proteobacteria;Haemophilus_sp._oral_taxon_851 | Saliva | A1s-A1Xs | 0.662037751 | 0.919761774 |
| Proteobacteria;Haemophilus_sputorum | Saliva | A1s-A1Xs | 0.540926649 | 0.841441454 |
| Proteobacteria;Lautropia_mirabilis | Saliva | A1s-A1Xs | 1 | 1 |
| Proteobacteria;Neisseria_elongata | Saliva | A1s-A1Xs | 0.871626643 | 1 |
| Proteobacteria;Ralstonia_sp._5_7_47FAA | Saliva | A1s-A1Xs | 0.353111235 | 0.670911346 |
| Proteobacteria;Rhodanobacter_sp._115 | Saliva | A1s-A1Xs | 0.827504996 | 0.997926198 |
| Saccharibacteria;TM7 | Saliva | A1s-A1Xs | 1 | 1 |
| Spirochaetes;Treponema_vincentii | Saliva | A1s-A1Xs | 0.161337629 | 0.412652013 |
| Actinobacteria;Actinomyces_sp._oral_taxon_849 | Saliva | A1s-A2s | 1 | 1 |
| Actinobacteria;Actinomyces_urogenitalis | Saliva | A1s-A2s | 0.570972361 | 0.85681253 |
| Actinobacteria;Rothia_mucilaginosa | Saliva | A1s-A2s | 1.39E-05 | 0.001228884 |
| Bacteroidetes;Prevotella_maculosa | Saliva | A1s-A2s | 0.009442444 | 0.069296138 |
| Bacteroidetes;Prevotella_oris | Saliva | A1s-A2s | 0.001874935 | 0.029008045 |
| Firmicutes;Dialister_invisus | Saliva | A1s-A2s | 0.007042085 | 0.060425633 |
| Firmicutes;Dialister_succinatiphilus | Saliva | A1s-A2s | 0.009638936 | 0.069296138 |
| Firmicutes;Enterococcus_italicus | Saliva | A1s-A2s | 8.81E-04 | 0.015619314 |
| Firmicutes;Gemella_sanguinis | Saliva | A1s-A2s | 0.012467358 | 0.079385837 |
| Firmicutes;Granulicatella_adiacens | Saliva | A1s-A2s | 0.016754361 | 0.09903689 |
| Firmicutes;Oribacterium_sinus | Saliva | A1s-A2s | 0.115874127 | 0.339014806 |
| Firmicutes;Oribacterium_sp._ACB7 | Saliva | A1s-A2s | 0.06826431 | 0.257349988 |
| Firmicutes;Selenomonas_sp._oral_taxon_149 | Saliva | A1s-A2s | 0.012437618 | 0.079385837 |
| Firmicutes;Selenomonas_sputigena | Saliva | A1s-A2s | 0.003278695 | 0.039642406 |
| Firmicutes;Streptococcus_cristatus | Saliva | A1s-A2s | 0.094478994 | 0.31026435 |
| Firmicutes;Streptococcus_intermedius | Saliva | A1s-A2s | 0.007795875 | 0.060991258 |
| Firmicutes;Streptococcus_peroris | Saliva | A1s-A2s | 0.006618208 | 0.058681444 |
| Firmicutes;Streptococcus_porcinus | Saliva | A1s-A2s | 0.213771447 | 0.516938226 |
| Firmicutes;Streptococcus_pseudoporcinus | Saliva | A1s-A2s | 0.076452032 | 0.271149873 |
| Firmicutes;Streptococcus_sp._oral_taxon_056 | Saliva | A1s-A2s | 0.325476536 | 0.644299985 |
| Firmicutes;Streptococcus_sp._SK643 | Saliva | A1s-A2s | 0.007795875 | 0.060991258 |
| Firmicutes;Streptococcus_suis | Saliva | A1s-A2s | 0.004191754 | 0.045392206 |
| Firmicutes;Streptococcus_thermophilus | Saliva | A1s-A2s | 0.32193826 | 0.644299985 |
| Firmicutes;Streptococcus_vestibularis | Saliva | A1s-A2s | 0.115874127 | 0.339014806 |
| Firmicutes;Veillonella_sp._oral_taxon_780 | Saliva | A1s-A2s | 0.213164932 | 0.516938226 |
| Proteobacteria;Aggregatibacter_segnis | Saliva | A1s-A2s | 0.010699012 | 0.074893087 |
| Proteobacteria;Campylobacter_concisus | Saliva | A1s-A2s | 6.78E-05 | 0.00257649 |
| Proteobacteria;Campylobacter_gracilis | Saliva | A1s-A2s | 0.012534606 | 0.079385837 |
| Proteobacteria;Campylobacter_showae | Saliva | A1s-A2s | 7.08E-04 | 0.015619314 |
| Proteobacteria;Haemophilus_parainfluenzae | Saliva | A1s-A2s | 0.016754361 | 0.09903689 |
| Proteobacteria;Haemophilus_sp._oral_taxon_851 | Saliva | A1s-A2s | 0.018578709 | 0.10295701 |
| Proteobacteria;Haemophilus_sputorum | Saliva | A1s-A2s | 0.054254548 | 0.209155214 |
| Proteobacteria;Lautropia_mirabilis | Saliva | A1s-A2s | 0.677378096 | 0.933588464 |
| Proteobacteria;Neisseria_elongata | Saliva | A1s-A2s | 0.366755061 | 0.676841283 |
| Proteobacteria;Ralstonia_sp._5_7_47FAA | Saliva | A1s-A2s | 0.005667219 | 0.057980009 |
| Proteobacteria;Rhodanobacter_sp._115 | Saliva | A1s-A2s | 0.218344898 | 0.517599378 |
| Saccharibacteria;TM7 | Saliva | A1s-A2s | 4.83E-05 | 0.002491075 |
| Spirochaetes;Treponema_vincentii | Saliva | A1s-A2s | 0.009638936 | 0.069296138 |
| Actinobacteria;Actinomyces_sp._oral_taxon_849 | Saliva | A1s-B1s | 0.093215724 | 0.31026435 |
| Actinobacteria;Actinomyces_urogenitalis | Saliva | A1s-B1s | 0.195712209 | 0.484757081 |
| Actinobacteria;Rothia_mucilaginosa | Saliva | A1s-B1s | 0.651618721 | 0.91226621 |
| Bacteroidetes;Prevotella_maculosa | Saliva | A1s-B1s | 0.217165544 | 0.517599378 |
| Bacteroidetes;Prevotella_oris | Saliva | A1s-B1s | 0.600426386 | 0.871272914 |
| Firmicutes;Dialister_invisus | Saliva | A1s-B1s | 0.843229141 | 0.997926198 |
| Firmicutes;Dialister_succinatiphilus | Saliva | A1s-B1s | 0.10437015 | 0.330505474 |
| Firmicutes;Enterococcus_italicus | Saliva | A1s-B1s | 0.450872242 | 0.764232591 |
| Firmicutes;Gemella_sanguinis | Saliva | A1s-B1s | 0.15830939 | 0.408837843 |
| Firmicutes;Granulicatella_adiacens | Saliva | A1s-B1s | 0.914475373 | 1 |
| Firmicutes;Oribacterium_sinus | Saliva | A1s-B1s | 0.561290794 | 0.848314496 |
| Firmicutes;Oribacterium_sp._ACB7 | Saliva | A1s-B1s | 0.052004482 | 0.203429296 |
| Firmicutes;Selenomonas_sp._oral_taxon_149 | Saliva | A1s-B1s | 0.844110506 | 0.997926198 |
| Firmicutes;Selenomonas_sputigena | Saliva | A1s-B1s | 0.775710035 | 0.985855076 |
| Firmicutes;Streptococcus_cristatus | Saliva | A1s-B1s | 0.561290794 | 0.848314496 |
| Firmicutes;Streptococcus_intermedius | Saliva | A1s-B1s | 0.532545466 | 0.838207657 |
| Firmicutes;Streptococcus_peroris | Saliva | A1s-B1s | 0.948623237 | 1 |
| Firmicutes;Streptococcus_porcinus | Saliva | A1s-B1s | 0.26853333 | 0.595248882 |
| Firmicutes;Streptococcus_pseudoporcinus | Saliva | A1s-B1s | 0.093810279 | 0.31026435 |
| Firmicutes;Streptococcus_sp._oral_taxon_056 | Saliva | A1s-B1s | 0.069658643 | 0.257349988 |
| Firmicutes;Streptococcus_sp._SK643 | Saliva | A1s-B1s | 0.948623237 | 1 |
| Firmicutes;Streptococcus_suis | Saliva | A1s-B1s | 0.073197952 | 0.265462839 |
| Firmicutes;Streptococcus_thermophilus | Saliva | A1s-B1s | 0.017606971 | 0.101814226 |
| Firmicutes;Streptococcus_vestibularis | Saliva | A1s-B1s | 0.045874973 | 0.190667855 |
| Firmicutes;Veillonella_sp._oral_taxon_780 | Saliva | A1s-B1s | 0.047556398 | 0.194615414 |
| Proteobacteria;Aggregatibacter_segnis | Saliva | A1s-B1s | 0.498527182 | 0.808586771 |
| Proteobacteria;Campylobacter_concisus | Saliva | A1s-B1s | 0.122524006 | 0.345929986 |
| Proteobacteria;Campylobacter_gracilis | Saliva | A1s-B1s | 0.856313971 | 1 |
| Proteobacteria;Campylobacter_showae | Saliva | A1s-B1s | 0.342377906 | 0.659945818 |
| Proteobacteria;Haemophilus_parainfluenzae | Saliva | A1s-B1s | 0.376588383 | 0.676841283 |
| Proteobacteria;Haemophilus_sp._oral_taxon_851 | Saliva | A1s-B1s | 0.525051924 | 0.831332213 |
| Proteobacteria;Haemophilus_sputorum | Saliva | A1s-B1s | 0.112069791 | 0.339014806 |
| Proteobacteria;Lautropia_mirabilis | Saliva | A1s-B1s | 0.069418531 | 0.257349988 |
| Proteobacteria;Neisseria_elongata | Saliva | A1s-B1s | 0.196818665 | 0.484757081 |
| Proteobacteria;Ralstonia_sp._5_7_47FAA | Saliva | A1s-B1s | 0.369673441 | 0.676841283 |
| Proteobacteria;Rhodanobacter_sp._115 | Saliva | A1s-B1s | 0.663888198 | 0.919761774 |
| Saccharibacteria;TM7 | Saliva | A1s-B1s | 0.600889362 | 0.871272914 |
| Spirochaetes;Treponema_vincentii | Saliva | A1s-B1s | 0.689764282 | 0.945759274 |
| Actinobacteria;Actinomyces_sp._oral_taxon_849 | Saliva | A2s-A2Ss | 0.274830794 | 0.604173481 |
| Actinobacteria;Actinomyces_urogenitalis | Saliva | A2s-A2Ss | 0.774588648 | 0.985855076 |
| Actinobacteria;Rothia_mucilaginosa | Saliva | A2s-A2Ss | 0.829983797 | 0.997926198 |
| Bacteroidetes;Prevotella_maculosa | Saliva | A2s-A2Ss | 0.576576853 | 0.85681253 |
| Bacteroidetes;Prevotella_oris | Saliva | A2s-A2Ss | 0.429599517 | 0.737248204 |
| Firmicutes;Dialister_invisus | Saliva | A2s-A2Ss | 0.375386249 | 0.676841283 |
| Firmicutes;Dialister_succinatiphilus | Saliva | A2s-A2Ss | 0.303023564 | 0.644299985 |
| Firmicutes;Enterococcus_italicus | Saliva | A2s-A2Ss | 0.609290034 | 0.876060265 |
| Firmicutes;Gemella_sanguinis | Saliva | A2s-A2Ss | 0.720314184 | 0.953251607 |
| Firmicutes;Granulicatella_adiacens | Saliva | A2s-A2Ss | 0.829983797 | 0.997926198 |
| Firmicutes;Oribacterium_sinus | Saliva | A2s-A2Ss | 0.550177931 | 0.848314496 |
| Firmicutes;Oribacterium_sp._ACB7 | Saliva | A2s-A2Ss | 0.279954034 | 0.605429049 |
| Firmicutes;Selenomonas_sp._oral_taxon_149 | Saliva | A2s-A2Ss | 0.980971668 | 1 |
| Firmicutes;Selenomonas_sputigena | Saliva | A2s-A2Ss | 0.375386249 | 0.676841283 |
| Firmicutes;Streptococcus_cristatus | Saliva | A2s-A2Ss | 0.458268747 | 0.766663438 |
| Firmicutes;Streptococcus_intermedius | Saliva | A2s-A2Ss | 0.002275168 | 0.029894271 |
| Firmicutes;Streptococcus_peroris | Saliva | A2s-A2Ss | 0.154582293 | 0.403126371 |
| Firmicutes;Streptococcus_porcinus | Saliva | A2s-A2Ss | 1 | 1 |
| Firmicutes;Streptococcus_pseudoporcinus | Saliva | A2s-A2Ss | 0.867643127 | 1 |
| Firmicutes;Streptococcus_sp._oral_taxon_056 | Saliva | A2s-A2Ss | 0.325476536 | 0.644299985 |
| Firmicutes;Streptococcus_sp._SK643 | Saliva | A2s-A2Ss | 0.302163095 | 0.644299985 |
| Firmicutes;Streptococcus_suis | Saliva | A2s-A2Ss | 0.324157856 | 0.644299985 |
| Firmicutes;Streptococcus_thermophilus | Saliva | A2s-A2Ss | 0.401761873 | 0.711511435 |
| Firmicutes;Streptococcus_vestibularis | Saliva | A2s-A2Ss | 0.25884048 | 0.585569067 |
| Firmicutes;Veillonella_sp._oral_taxon_780 | Saliva | A2s-A2Ss | 0.787772175 | 0.985855076 |
| Proteobacteria;Aggregatibacter_segnis | Saliva | A2s-A2Ss | 0.279954034 | 0.605429049 |
| Proteobacteria;Campylobacter_concisus | Saliva | A2s-A2Ss | 0.140752207 | 0.371752149 |
| Proteobacteria;Campylobacter_gracilis | Saliva | A2s-A2Ss | 0.788920769 | 0.985855076 |
| Proteobacteria;Campylobacter_showae | Saliva | A2s-A2Ss | 0.770897292 | 0.985855076 |
| Proteobacteria;Haemophilus_parainfluenzae | Saliva | A2s-A2Ss | 0.219882443 | 0.517599378 |
| Proteobacteria;Haemophilus_sp._oral_taxon_851 | Saliva | A2s-A2Ss | 0.720314184 | 0.953251607 |
| Proteobacteria;Haemophilus_sputorum | Saliva | A2s-A2Ss | 0.238822532 | 0.557252575 |
| Proteobacteria;Lautropia_mirabilis | Saliva | A2s-A2Ss | 0.941472333 | 1 |
| Proteobacteria;Neisseria_elongata | Saliva | A2s-A2Ss | 0.789425305 | 0.985855076 |
| Proteobacteria;Ralstonia_sp._5_7_47FAA | Saliva | A2s-A2Ss | 0.827390383 | 0.997926198 |
| Proteobacteria;Rhodanobacter_sp._115 | Saliva | A2s-A2Ss | 3.01E-04 | 0.008016039 |
| Saccharibacteria;TM7 | Saliva | A2s-A2Ss | 0.48139587 | 0.787230675 |
| Spirochaetes;Treponema_vincentii | Saliva | A2s-A2Ss | 0.941661916 | 1 |
| Actinobacteria;Actinomyces_sp._oral_taxon_849 | Saliva | B1s-B1Ss | 0.11597875 | 0.339014806 |
| Actinobacteria;Actinomyces_urogenitalis | Saliva | B1s-B1Ss | 0.097166967 | 0.312552435 |
| Actinobacteria;Rothia_mucilaginosa | Saliva | B1s-B1Ss | 0.412375778 | 0.716940895 |
| Bacteroidetes;Prevotella_maculosa | Saliva | B1s-B1Ss | 0.307364925 | 0.644299985 |
| Bacteroidetes;Prevotella_oris | Saliva | B1s-B1Ss | 0.950384432 | 1 |
| Firmicutes;Dialister_invisus | Saliva | B1s-B1Ss | 0.505967063 | 0.810766498 |
| Firmicutes;Dialister_succinatiphilus | Saliva | B1s-B1Ss | 0.35064789 | 0.670911346 |
| Firmicutes;Enterococcus_italicus | Saliva | B1s-B1Ss | 0.106445694 | 0.333112406 |
| Firmicutes;Gemella_sanguinis | Saliva | B1s-B1Ss | 0.324548175 | 0.644299985 |
| Firmicutes;Granulicatella_adiacens | Saliva | B1s-B1Ss | 0.032943642 | 0.153722573 |
| Firmicutes;Oribacterium_sinus | Saliva | B1s-B1Ss | 0.838134777 | 0.997926198 |
| Firmicutes;Oribacterium_sp._ACB7 | Saliva | B1s-B1Ss | 0.616465037 | 0.876896791 |
| Firmicutes;Selenomonas_sp._oral_taxon_149 | Saliva | B1s-B1Ss | 0.558988678 | 0.848314496 |
| Firmicutes;Selenomonas_sputigena | Saliva | B1s-B1Ss | 0.258256792 | 0.585569067 |
| Firmicutes;Streptococcus_cristatus | Saliva | B1s-B1Ss | 0.00196295 | 0.029008045 |
| Firmicutes;Streptococcus_intermedius | Saliva | B1s-B1Ss | 0.09752576 | 0.312552435 |
| Firmicutes;Streptococcus_peroris | Saliva | B1s-B1Ss | 0.806333778 | 0.988409148 |
| Firmicutes;Streptococcus_porcinus | Saliva | B1s-B1Ss | 4.28E-04 | 0.010357423 |
| Firmicutes;Streptococcus_pseudoporcinus | Saliva | B1s-B1Ss | 9.87E-05 | 0.003280212 |
| Firmicutes;Streptococcus_sp._oral_taxon_056 | Saliva | B1s-B1Ss | 1.74E-04 | 0.005146773 |
| Firmicutes;Streptococcus_sp._SK643 | Saliva | B1s-B1Ss | 0.967417298 | 1 |
| Firmicutes;Streptococcus_suis | Saliva | B1s-B1Ss | 0.002096373 | 0.029349216 |
| Firmicutes;Streptococcus_thermophilus | Saliva | B1s-B1Ss | 0.002360074 | 0.029894271 |
| Firmicutes;Streptococcus_vestibularis | Saliva | B1s-B1Ss | 0.029417889 | 0.140108255 |
| Firmicutes;Veillonella_sp._oral_taxon_780 | Saliva | B1s-B1Ss | 0.575867202 | 0.85681253 |
| Proteobacteria;Aggregatibacter_segnis | Saliva | B1s-B1Ss | 0.073850564 | 0.265462839 |
| Proteobacteria;Campylobacter_concisus | Saliva | B1s-B1Ss | 0.038002593 | 0.170303502 |
| Proteobacteria;Campylobacter_gracilis | Saliva | B1s-B1Ss | 0.715600392 | 0.953251607 |
| Proteobacteria;Campylobacter_showae | Saliva | B1s-B1Ss | 0.451069612 | 0.764232591 |
| Proteobacteria;Haemophilus_parainfluenzae | Saliva | B1s-B1Ss | 0.126147401 | 0.345929986 |
| Proteobacteria;Haemophilus_sp._oral_taxon_851 | Saliva | B1s-B1Ss | 0.42439585 | 0.733047378 |
| Proteobacteria;Haemophilus_sputorum | Saliva | B1s-B1Ss | 0.870194456 | 1 |
| Proteobacteria;Lautropia_mirabilis | Saliva | B1s-B1Ss | 0.917402105 | 1 |
| Proteobacteria;Neisseria_elongata | Saliva | B1s-B1Ss | 1 | 1 |
| Proteobacteria;Ralstonia_sp._5_7_47FAA | Saliva | B1s-B1Ss | 1 | 1 |
| Proteobacteria;Rhodanobacter_sp._115 | Saliva | B1s-B1Ss | 0.897680214 | 1 |
| Saccharibacteria;TM7 | Saliva | B1s-B1Ss | 0.614620907 | 0.876896791 |
| Spirochaetes;Treponema_vincentii | Saliva | B1s-B1Ss | 0.882112318 | 1 |
| Actinobacteria;Actinomyces_sp._oral_taxon_849 | Saliva | B1s-B2s | 0.126147401 | 0.345929986 |
| Actinobacteria;Actinomyces_urogenitalis | Saliva | B1s-B2s | 0.463214051 | 0.770093361 |
| Actinobacteria;Rothia_mucilaginosa | Saliva | B1s-B2s | 5.62E-05 | 0.002491075 |
| Bacteroidetes;Prevotella_maculosa | Saliva | B1s-B2s | 0.180285455 | 0.456723152 |
| Bacteroidetes;Prevotella_oris | Saliva | B1s-B2s | 0.092947853 | 0.31026435 |
| Firmicutes;Dialister_invisus | Saliva | B1s-B2s | 0.01991441 | 0.107122963 |
| Firmicutes;Dialister_succinatiphilus | Saliva | B1s-B2s | 0.025238903 | 0.126670722 |
| Firmicutes;Enterococcus_italicus | Saliva | B1s-B2s | 0.020135895 | 0.107122963 |
| Firmicutes;Gemella_sanguinis | Saliva | B1s-B2s | 3.43E-05 | 0.002282437 |
| Firmicutes;Granulicatella_adiacens | Saliva | B1s-B2s | 0.007543545 | 0.060991258 |
| Firmicutes;Oribacterium_sinus | Saliva | B1s-B2s | 0.018553726 | 0.10295701 |
| Firmicutes;Oribacterium_sp._ACB7 | Saliva | B1s-B2s | 0.259763722 | 0.585569067 |
| Firmicutes;Selenomonas_sp._oral_taxon_149 | Saliva | B1s-B2s | 0.051213548 | 0.203325427 |
| Firmicutes;Selenomonas_sputigena | Saliva | B1s-B2s | 0.027907646 | 0.137470998 |
| Firmicutes;Streptococcus_cristatus | Saliva | B1s-B2s | 0.023496147 | 0.12254853 |
| Firmicutes;Streptococcus_intermedius | Saliva | B1s-B2s | 0.950334739 | 1 |
| Firmicutes;Streptococcus_peroris | Saliva | B1s-B2s | 0.004266185 | 0.045392206 |
| Firmicutes;Streptococcus_porcinus | Saliva | B1s-B2s | 0.038414324 | 0.170303502 |
| Firmicutes;Streptococcus_pseudoporcinus | Saliva | B1s-B2s | 0.557807611 | 0.848314496 |
| Firmicutes;Streptococcus_sp._oral_taxon_056 | Saliva | B1s-B2s | 0.712965125 | 0.953251607 |
| Firmicutes;Streptococcus_sp._SK643 | Saliva | B1s-B2s | 8.34E-04 | 0.015619314 |
| Firmicutes;Streptococcus_suis | Saliva | B1s-B2s | 0.141154012 | 0.371752149 |
| Firmicutes;Streptococcus_thermophilus | Saliva | B1s-B2s | 1 | 1 |
| Firmicutes;Streptococcus_vestibularis | Saliva | B1s-B2s | 0.633325915 | 0.891347583 |
| Firmicutes;Veillonella_sp._oral_taxon_780 | Saliva | B1s-B2s | 0.263174191 | 0.588271721 |
| Proteobacteria;Aggregatibacter_segnis | Saliva | B1s-B2s | 0.025086713 | 0.126670722 |
| Proteobacteria;Campylobacter_concisus | Saliva | B1s-B2s | 5.16E-08 | 1.37E-05 |
| Proteobacteria;Campylobacter_gracilis | Saliva | B1s-B2s | 0.011760504 | 0.079385837 |
| Proteobacteria;Campylobacter_showae | Saliva | B1s-B2s | 0.001789949 | 0.029008045 |
| Proteobacteria;Haemophilus_parainfluenzae | Saliva | B1s-B2s | 0.006568052 | 0.058681444 |
| Proteobacteria;Haemophilus_sp._oral_taxon_851 | Saliva | B1s-B2s | 0.00599101 | 0.058681444 |
| Proteobacteria;Haemophilus_sputorum | Saliva | B1s-B2s | 3.51E-06 | 4.66E-04 |
| Proteobacteria;Lautropia_mirabilis | Saliva | B1s-B2s | 0.044229415 | 0.186746419 |
| Proteobacteria;Neisseria_elongata | Saliva | B1s-B2s | 8.40E-04 | 0.015619314 |
| Proteobacteria;Ralstonia_sp._5_7_47FAA | Saliva | B1s-B2s | 0.044014389 | 0.186746419 |
| Proteobacteria;Rhodanobacter_sp._115 | Saliva | B1s-B2s | 0.405816604 | 0.711511435 |
| Saccharibacteria;TM7 | Saliva | B1s-B2s | 0.006451566 | 0.058681444 |
| Spirochaetes;Treponema_vincentii | Saliva | B1s-B2s | 0.015395201 | 0.095235429 |
| Actinobacteria;Actinomyces_sp._oral_taxon_849 | Saliva | B2s-B2Xs | 0.512486352 | 0.816295627 |
| Actinobacteria;Actinomyces_urogenitalis | Saliva | B2s-B2Xs | 0.473869552 | 0.782914911 |
| Actinobacteria;Rothia_mucilaginosa | Saliva | B2s-B2Xs | 0.029496475 | 0.140108255 |
| Bacteroidetes;Prevotella_maculosa | Saliva | B2s-B2Xs | 0.833499632 | 0.997926198 |
| Bacteroidetes;Prevotella_oris | Saliva | B2s-B2Xs | 0.319290549 | 0.644299985 |
| Firmicutes;Dialister_invisus | Saliva | B2s-B2Xs | 0.90092763 | 1 |
| Firmicutes;Dialister_succinatiphilus | Saliva | B2s-B2Xs | 0.885475367 | 1 |
| Firmicutes;Enterococcus_italicus | Saliva | B2s-B2Xs | 0.724121124 | 0.953545638 |
| Firmicutes;Gemella_sanguinis | Saliva | B2s-B2Xs | 0.366875192 | 0.676841283 |
| Firmicutes;Granulicatella_adiacens | Saliva | B2s-B2Xs | 0.967417298 | 1 |
| Firmicutes;Oribacterium_sinus | Saliva | B2s-B2Xs | 0.712965125 | 0.953251607 |
| Firmicutes;Oribacterium_sp._ACB7 | Saliva | B2s-B2Xs | 0.504247169 | 0.810766498 |
| Firmicutes;Selenomonas_sp._oral_taxon_149 | Saliva | B2s-B2Xs | 0.870194456 | 1 |
| Firmicutes;Selenomonas_sputigena | Saliva | B2s-B2Xs | 0.743702065 | 0.964998778 |
| Firmicutes;Streptococcus_cristatus | Saliva | B2s-B2Xs | 0.9348872 | 1 |
| Firmicutes;Streptococcus_intermedius | Saliva | B2s-B2Xs | 0.118401403 | 0.342334492 |
| Firmicutes;Streptococcus_peroris | Saliva | B2s-B2Xs | 0.53929854 | 0.841441454 |
| Firmicutes;Streptococcus_porcinus | Saliva | B2s-B2Xs | 0.079725196 | 0.275414312 |
| Firmicutes;Streptococcus_pseudoporcinus | Saliva | B2s-B2Xs | 0.961707797 | 1 |
| Firmicutes;Streptococcus_sp._oral_taxon_056 | Saliva | B2s-B2Xs | 0.124692525 | 0.345929986 |
| Firmicutes;Streptococcus_sp._SK643 | Saliva | B2s-B2Xs | 0.366875192 | 0.676841283 |
| Firmicutes;Streptococcus_suis | Saliva | B2s-B2Xs | 0.329416534 | 0.644299985 |
| Firmicutes;Streptococcus_thermophilus | Saliva | B2s-B2Xs | 0.389422616 | 0.695210844 |
| Firmicutes;Streptococcus_vestibularis | Saliva | B2s-B2Xs | 0.455101207 | 0.766183044 |
| Firmicutes;Veillonella_sp._oral_taxon_780 | Saliva | B2s-B2Xs | 0.878026982 | 1 |
| Proteobacteria;Aggregatibacter_segnis | Saliva | B2s-B2Xs | 0.774840302 | 0.985855076 |
| Proteobacteria;Campylobacter_concisus | Saliva | B2s-B2Xs | 0.324548175 | 0.644299985 |
| Proteobacteria;Campylobacter_gracilis | Saliva | B2s-B2Xs | 0.90092763 | 1 |
| Proteobacteria;Campylobacter_showae | Saliva | B2s-B2Xs | 0.803376862 | 0.988409148 |
| Proteobacteria;Haemophilus_parainfluenzae | Saliva | B2s-B2Xs | 1 | 1 |
| Proteobacteria;Haemophilus_sp._oral_taxon_851 | Saliva | B2s-B2Xs | 0.966900055 | 1 |
| Proteobacteria;Haemophilus_sputorum | Saliva | B2s-B2Xs | 0.9348872 | 1 |
| Proteobacteria;Lautropia_mirabilis | Saliva | B2s-B2Xs | 0.406577963 | 0.711511435 |
| Proteobacteria;Neisseria_elongata | Saliva | B2s-B2Xs | 0.191313092 | 0.48008757 |
| Proteobacteria;Ralstonia_sp._5_7_47FAA | Saliva | B2s-B2Xs | 0.120758587 | 0.34539553 |
| Proteobacteria;Rhodanobacter_sp._115 | Saliva | B2s-B2Xs | 0.003625355 | 0.041928016 |
| Saccharibacteria;TM7 | Saliva | B2s-B2Xs | 0.785497119 | 0.985855076 |
| Spirochaetes;Treponema_vincentii | Saliva | B2s-B2Xs | 1 | 1 |
p < 0.05 are highlighted in bold.