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. 2018 Aug 27;23(9):2149. doi: 10.3390/molecules23092149

Figure 1.

Figure 1

Figure 1

Zeylenone (Zey) effectively suppresses cell viability and colony formation in SGC7901 and MGC803 cells. (A) Chemical structure of Zey. (B) Zey suppresses the viability of SGC7901 and MGC803 cells determined in an MTT assay. Cells were treated with Zey (0, 2.96, 5.92, 11.84, 23.68, or 47.37 μM) for 24 h. Data are expressed as means ± SD of three distinct experiments. The cell viability of the control (DMSO only) is indicated as 100%. * p < 0.05 and ** p < 0.01 vs. control cells. (C) Zey suppresses the viability of normal gastric epithelial (GES-1) cells determined in an MTT assay. GES-1 cells were treated with Zey (0, 1, 2, 4, 8, 16, 32, 64, or 128 μM) for 24 h. Data are expressed as means ± SD of three distinct experiments. * p < 0.05 and ** p < 0.01 vs. control cells. (D) Representative images of colonies after SGC7901 and MGC803 cells were treated with Zey for 12 days. (E) Statistical analysis of colony numbers from three independent experiments. * p < 0.05 and ** p < 0.01 vs. control cells.