Table 1.
Biological assays on compounds 1 to 6.
| eeAChEi IC50 (μM ± SEM) | esBChEi IC50 (μM ± SEM) | Antioxidant Activity EC50 (μmol/µmol of DPPH ± SEM) | iAβ IC50 (μM ± SEM) | |
|---|---|---|---|---|
| Galantamine | 0.51 ± 0.10 | 8.70 ± 1.02 | n.d. | n.d. |
| Gallic acid | n.d. | n.d. | 0.054 ± 0.004 | n.d. |
| Quercetin | n.d. | n.d. | n.d. | 0.82 ± 0.07 |
| Clioquinol | 8.12 ± 1.00 | %I (10μM): 10 ± 1% | 0.74 ± 0.04 | 7.6 ± 0.8 |
| 1 | 8.13 ± 0.08 | %I (10μM): 7 ± 1% | 2.6 ± 0.2 | %I (100μM): 50 ± 8 |
| 2 | 6.86 ± 0.67 | i.a. | > 100 | 74 ± 1 |
| 3 | 7.84 ± 0.72 | i.a. | 14.7 ± 3.4 | %I (100μM): 38 ± 3 |
| 4 | 11.4 ± 0.8 | %I (10μM): 10 ± 3% | > 100 | 98 ± 3 |
| 5 | 8.96 ± 0.97 | %I (10μM): 6 ± 1% | >100 | %I (100μM): 44 ± 3 |
| 6 | 86.0 ± 15.0 | 1.75 ± 0.59 | >100 | %I (100μM): 33 ± 9 |
eeAChEi = inhibition of acetylcholinesterase from electric eel. esBChEi = inhibition of butyrylcholinesterase from equine serum. iAβ = inhibition of Aβ1–40 aggregation. % I = percentage of inhibition at 100 μM. i.a. = not active. n.d. = not determined.