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. 2018 Oct 18;25(1):1846–1857. doi: 10.1080/10717544.2018.1486472

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Pharmacodynamics evaluation of sPEG/HA/CSO-SS-Hex/Fe₃O₄/GA in vivo. (A) Mean blood concentration–time curve of Sprague Dawley female rats after caudal vein administration of sPEG/HA/CSO-SS-Hex/Fe₃O₄/GA micelles and free GA (Each value represents the mean ± SD, n = 6). (B and C) In vivo fluorescence images of tumor-bearing mice acquired after injecting DiR-conjugated sPEG/HA/CSO-SS-Hex/Fe₃O₄/DiR micelles suspensions, it showed the tumor not exposing (MF-) or exposing (MF+) to magnetic fields at 24 h (B), while (C) showed the tumor exposing to magnetic fields at different time points (the red circle indicates an area of tumor position).