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. 2018 Nov 7;25(1):1886–1897. doi: 10.1080/10717544.2018.1486473

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — The in vivo noninvasive images of time-dependent whole body imaging of PM mice co-infected with S. pneumonia ATCC 49619 and S. pneumonia 16167 after i.v. injection of DiR-loaded RVG₂₉-Nano-BA_P85, RVG₂₉-Nano-BA, Nano-BA_P85, Nano-BA, and PEGylated Nano-BA_12K (A). The ex vivo optical images of the brain (B) and other organs (C) of the PM mice co-infected with S. pneumonia ATCC 49619 and S. pneumonia 16167 after i.v. injection of DiR-loaded RVG₂₉-Nano-BA_P85, RVG₂₉-Nano-BA, Nano-BA_P85, Nano-BA, and PEGylated Nano-BA_12K. Quantitative analysis for accumulation in the brain of BA in the PM mice co-infected with S. pneumonia ATCC 49619 and S. pneumonia 16167 at different times after intravenous administration of RVG₂₉-Nano-BA_P85, RVG₂₉-Nano-BA, Nano-BA_P85, Nano-BA, and PEGylated Nano-BA_12K at a dose of 30 mg/kg, respectively (D).