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. 2018 Nov 8;9:294. doi: 10.1186/s13287-018-1014-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Matrigel plug assay shows that FE promotes angiogenesis in vivo. a PBS and FE of low and high concentrations mixed with Matrigel and injected subcutaneously into dorsal region of nude mice. Matrigel plugs harvested at 1 week post implantation. Left panel: gross morphology of Matrigel plugs. Right panel: hematoxylin–eosin (H&E) staining of paraffin sections of explanted plugs. Tissue with more blood vessels observed in FE^High plugs. Arrows indicate formed blood vessels. b Immunostaining of Matrigel plug with CD31 antibody. FE^High group showed more CD31⁺ blood vessels. c Quantification of CD31⁺ capillary density. Significantly higher blood vessel density measured in FE^High-treated group. d Immunostaining of mouse macrophage marker CD68 on Matrigel plugs. FE^High group showed more CD68⁺ cells. e Quantification of CD68⁺ cells. Significantly higher number of CD68⁺ cells observed in FE^High-treated group. *p < 0.05. PBS phosphate-buffered saline