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. 2018 Nov 8;19:809. doi: 10.1186/s12864-018-5166-z

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — RIVET analysis of polysome profiling data with multiple polysome fractions. a. Heatmap from translation module, polysome sub-tab, of fold-changes of eIF4E silencing compared to control in MCF7 cells in heavy (> 4 ribosomes) or light (2–3 ribosomes). Fold-changes are either upregulated (in blue) across the gradient or downregulated (in red) b. Translational regulation scatter plot with types of translational regulation highlighted in different colors. The threshold for regulation was set at translation > 4 fold and transcription > 1 fold in the translation and transcription modules respectively. c. Heatmap of mRNAs selected to have a translational efficiency > 1 fold, p-value < 0.05 in either heavy or light polysome fractions. Fold-changes correspond to eIF4E silencing compared to control in polysome fractions