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. 2018 Nov 8;6:122. doi: 10.1186/s40478-018-0627-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Motor neuron degeneration in ChATtTA/UBQLN2^P497H rats. a-d Representative images of cresyl violet staining revealed the motor neurons of the lumbar spinal cord. e A graph showing the relative ratio of the motor neurons of the L3–5 spinal cord counted using ImageJ software. This graph shows that there was a mild loss of motor neurons in ChATtTA/UBQLN2^P497H rats (P497H) at 12 months old. The “m” denotes month in this graph. The data are reported as the mean ± standard deviation (n = 4). *p < 0.05. f-i Bielschowsky’s silver staining showed degenerating motor neurons in the ventral horn of spinal cord in ChATtTA/UBQLN2^P497H but not in ChATtTA rats. j-k Toluidine staining revealed the L3 ventral roots of spinal cords. l The motor axons of L3 ventral roots were counted with ImageJ software. The data are shown as the mean ± standard deviation (n = 4 rats). Scale bars: 50 μm (a-d), 30 μm (f-k)