Table 2.
Adjusted odds ratios (95% confidence intervals) of NAFLD according to sex and serum SHBG quartiles using adjusted logistic regression
| SHBG (nmol/L) | p for trend | ||||
|---|---|---|---|---|---|
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | ||
| Total (N = 2912) | < 38.70 | 38.70–52.45 | 52.46–71.3 | > 71.3 | |
| Model 1 | 1.00 | 0.38 (0.30–0.48) | 0.21 (0.16–0.26) | 0.09 (0.07–0.11) | < 0.001 |
| Model 2 | 1.00 | 0.46 (0.36–0.59) | 0.30 (0.23–0.38) | 0.18 (0.13–0.23) | < 0.001 |
| Model 3 | 1.00 | 0.54 (0.42–0.70) | 0.38 (0.29–0.50) | 0.24 (0.18–0.32) | < 0.001 |
| Females (N = 2009) | < 40.65 | 40.65–55.70 | 55.71–75.80 | > 75.80 | |
| Model 1 | 1.00 | 0.34 (0.25–0.45) | 0.18 (0.14–0.24) | 0.07 (0.05–0.09) | < 0.001 |
| Model 2 | 1.00 | 0.40 (0.30–0.54) | 0.24 (0.18–0.33) | 0.13 (0.09–0.18) | < 0.001 |
| Model 3 | 1.00 | 0.49 (0.36–0.67) | 0.33 (0.24–0.45) | 0.19 (0.13–0.27) | < 0.001 |
| Males (N = 903) | < 35.50 | 35.50–47.10 | 47.11–61.00 | > 61.00 | |
| Model 1 | 1.00 | 0.67 (0.45–1.00) | 0.31 (0.21–0.46) | 0.13 (0.09–0.21) | < 0.001 |
| Model 2 | 1.00 | 0.83 (0.53–1.29) | 0.47 (0.30–0.73) | 0.35 (0.22–0.57) | < 0.001 |
| Model 3 | 1.00 | 0.95 (0.59–1.53) | 0.57 (0.35–0.95) | 0.42 (0.23–0.77) | 0.001 |
Model 1: Adjusted for age, sex, postmenopausal status (for females) and household income
Model 2: Adjusted for the variables in Model 1 plus WHR, trunk fat, current smoking and drinking, physical activity (MET), hypertension and diabetes
Model 3: Adjusted for the variables in Model 2 plus serum glucose, insulin resistance (HOMA-IR), TG, HDL-C, ALT, UA, testosterone and DHEAS levels
NAFLD, nonalcoholic fatty liver disease; SHBG, sex hormone-binding globulin