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. 2018 Nov 8;15:310. doi: 10.1186/s12974-018-1345-8

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© The Author(s). 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — ω-3 PUFA supplementation elevates SIRT1 expression and deacetylase activity in lesioned cortices 7 days after TBI. a SIRT1 immunoreactivity in both neurons and microglia from lesioned cortices was significantly increased by ω-3 PUFA supplementation (2.64 ± 0.47 vs 1.74 ± 0.33, p < 0.05). b SIRT1 levels were also upregulated after ω-3 PUFA supplementation (p < 0.05). c The NAD+/NADH ratio was measured to detect SIRT1 activity. Treatment with ω-3 PUFA significantly increased the NAD+/NADH ratio (p < 0.05). Values are expressed as mean ± standard deviation (n = 6 per group). N.S., p > 0.05, *p < 0.05, **p < 0.01. Scale bars = 50 μm