Table 5.
Top 20 (ranked) biomarker gene and their regulatory doses of chemical compound relationships for glutathione metabolism pathway and PPAR signaling pathway datasets.
| Glutathione metabolism pathway | PPAR signaling pathway | ||||
|---|---|---|---|---|---|
| Chemical compound and dose combination | Biomarker gene | Ranking score | Chemical compound and dose combination | Biomarker gene | Ranking score |
| acetaminophen_High | Gsta5 | 100.00 | WY14643_High | Ehhadh | 100.00 |
| nitrofurazone_High | Gsta5 | 96.26 | WY14643_High | Cyp4a1 | 97.29 |
| acetaminophen_Middle | Gsta5 | 91.69 | WY14643_Middle | Ehhadh | 95.32 |
| acetaminophen_High | G6pd | 90.85 | WY14643_Middle | Cyp4a1 | 93.17 |
| acetaminophen_High | Gpx2 | 89.67 | WY14643_High | Acaa1a | 92.41 |
| nitrofurazone_High | G6pd | 89.48 | clofibrate_High | Ehhadh | 88.93 |
| nitrofurazone_High | Gpx2 | 89.29 | WY14643_Middle | Acaa1a | 88.47 |
| acetaminophen_Middle | Gpx2 | 86.05 | clofibrate_High | Cyp4a1 | 87.34 |
| acetaminophen_Middle | G6pd | 85.91 | benzbromarone_High | Ehhadh | 87.04 |
| acetaminophen_High | Gsr | 85.19 | WY14643_High | Cyp4a3 | 86.68 |
| acetaminophen_High | Gstp1 | 83.54 | WY14643_Low | Ehhadh | 86.65 |
| nitrofurazone_High | Gsr | 83.25 | WY14643_High | Plin5 | 85.99 |
| nitrofurazone_High | Gstp1 | 81.53 | benzbromarone_High | Cyp4a1 | 85.67 |
| acetaminophen_High | Mgst2 | 80.46 | WY14643_Low | Cyp4a1 | 85.17 |
| acetaminophen_High | Gclc | 80.38 | WY14643_High | Cpt2 | 84.46 |
| methapyrilene_High | Gsta5 | 80.23 | WY14643_High | Cpt1b | 84.45 |
| acetaminophen_Middle | Gsr | 79.71 | WY14643_High | Angptl4 | 83.99 |
| acetaminophen_High | Gclm | 79.56 | aspirin_High | Ehhadh | 83.60 |
| methapyrilene_High | Gpx2 | 79.47 | WY14643_Middle | Cyp4a3 | 83.54 |
| nitrofurazone_High | Gclc | 78.93 | aspirin_High | Cyp4a1 | 83.10 |