Fig. 1 |. NK cells undergo dynamic chromatin changes during viral infection.

a, Schematic of timepoints assayed for time course of ATAC-seq (n = 3 or 4 samples per d) and RNA-seq profiling (n = 2 samples per d). b, Number of DA (false discovery rate (FDR) < 0.05) regions that either gain (red) or lose (blue) chromatin accessibility at indicated transition timepoints. c, Absolute numbers and proportions of all DA regions versus high-fold change (FC; absolute log₂(FC) > 1) regions. d, Shown are line graphs (left) and heatmap (right) of high-FC peaks. Line plots showing mean (red line) and s.d. (gray ribbon) of mean-centered normalized log₂ values for each high-FC cluster. Heatmap is hierarchically clustered based on all high-FC log₂ peak counts (see Supplementary Fig. 1e) and shows the top 10% most variable regions within each cluster, with stable and transient clusters as indicated. e, Heatmap of top 20 most enriched pathways of any high-FC cluster shown as −log₁₀ raw binomial P values, as calculated by Genomic Regions Enrichment of Annotations Tool (GREAT). TCR, T cell antigen receptor.