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Uptake of MB and hybrids 10, INF55(Ac)en−MB 12, and 14 by S. aureus isogenic NorA efflux mutants. All compounds were present at 20 μM. Data represent the mean ± SEM from three independent experiments. One-tailed t tests comparing MB uptake into each strain to uptake of each hybrid showed significant differences (***P < 0.001).
