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. 2018 Jul 16;71(11):981–988. doi: 10.1136/jclinpath-2018-205271

Figure 4.

Figure 4

Accuracy of different cervical intraepithelial neoplasia (CIN) grading strategies. The proportion of test positives for the different CIN grading strategies I–VII is shown separately within each Reference Standard: no dysplasia, CIN1, CIN2, CIN3 and cervical squamous cell carcinoma (SCC). The H&E score (strategies I and II) is based solely on morphologic characteristics, the H&E+immunohistochemistry (IHC) score (strategies III and IV) is rendered after interpretation of Ki-67 and p16ink4a immunostains, and the immunoscore (strategies V, VI and VII) is the total value of the scoring for Ki-67 and p16ink4a immunostains independently scored by the pathologist. Strategy VII detects the highest number of CIN3 and the fewest CIN1. The exact values for the proportion of test positives are shown in online supplementary table 1 and the absolute differences between all point values (indicated by ∆) are shown in online supplementary table 2.