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. 2018 Jul 16;71(11):981–988. doi: 10.1136/jclinpath-2018-205271

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© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Reproducibility of different cervical intraepithelial neoplasia (CIN) grading strategies. The absolute agreement among pathologists for the different CIN grading strategies I–VII, representing the reproducibility, is shown separately within each Reference Standard: no dysplasia, CIN1, CIN2, CIN3 and cervical squamous cell carcinoma (SCC). The H&E score (strategies I and II) is based solely on morphologic characteristics, the H&E+immunohistochemistry (IHC) score (strategies III and IV) is rendered after interpretation of Ki-67 and p16^ink4a immunostains, and the immunoscore (strategies V, VI and VII) is the total value of the scoring for Ki-67 and p16^ink4a immunostains independently scored by the pathologist. The exact values of absolute agreement are shown in online supplementary table 3.