Figure 3.

Impaired GR dimerisation in stromal cells abrogates suppression of serum transfer-induced arthritis (STIA) but does not affect cytokine suppression by glucocorticoids (GC). (A) Ankle thickness and clinical score of irradiated wt and GR^dim recipient mice reconstituted with wt bone marrow (wt→wt and wt→GR^dim) treated for 72 hours with PBS (black and red) or DEX (grey and blue). (B) Serum cytokine levels of IL-1β, TNFα and IFNγ are suppressed in both wt→wt and wt→GR^dim mice after DEX treatment. *p<0.05, group size n=5–6 mice per group. DEX, dexamethasone; GR, glucocorticoid receptor; IFN, interferon; IL, interleukin; PBS, phosphate buffered saline; TNF, tumour necrosis factor; wt, wild type.