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. 2018 Jul 11;77(11):1610–1618. doi: 10.1136/annrheumdis-2017-212762

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© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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The GR dimer in stromal cells mediates the induction of genes of anti-inflammatory macrophages after DEX treatment in serum transfer-induced arthritis (STIA). (A) Quantitative RT-PCR of isolated ankle mRNA extracts showing the regulation of CD163, CD36, AnxA1, Axl and MerTK after 72 hours of DEX treatment in wt→wt and wt→GR^dim mice. Group size n=5–6 mice per group. (B) Quantitative RT-PCR of isolated ankle mRNA extracts showing the regulation of CD163, CD36, AnxA1, Axl and MerTK after 10 days of DEX treatment in wt→wt and wt→GR^dim mice. Group size n=4–6 mice per group. *P<0.05; **P<0.01; ***P<0.001 by two-way analysis of variance (ANOVA) followed Tukey’s multiple comparison correction. DEX, dexamethasone; GR, glucocorticoid receptor; PBS, phosphate buffered saline.