Table 3.
Subgroup analysis of overall survival by tumor type, NOS score, sample size
| Subgroups | No of studies | No of patients | Pooled HR (95% CI) | PHet | I2 (%) | P-value |
|---|---|---|---|---|---|---|
|
| ||||||
| Tumor type | ||||||
| Respiratory system | 2 | 137 | 1.56 (0.99, 2.14) | 0.794 | 0.0 | >0.05 |
| Digestive system | 3 | 624 | 1.59 (1.25, 1.93) | 0.869 | 0.0 | <0.05 |
| Female reproductive system | 2 | 412 | 1.73 (0.90, 2.55) | 0.788 | 0.0 | >0.05 |
| Osteosarcoma | 2 | 89 | 1.63 (0.04, 3.21) | 0.788 | 0.0 | >0.05 |
| Melanoma | 1 | 25 | 1.72 (0.04, 3.21) | – | – | >0.05 |
| Sample size | ||||||
| ≤100 | 7 | 356 | 1.63 (1.34, 1.88) | 0.985 | 0.0 | <0.05 |
| >100 | 4 | 993 | 1.60 (1.29, 1.92) | 0.957 | 0.0 | <0.05 |
| NOS score | ||||||
| ≤7 | 6 | 586 | 1.63 (1.06, 2.19) | 0.978 | 0.0 | <0.05 |
| >7 | 5 | 763 | 1.60 (1.30, 1.91) | 0.968 | 0.0 | <0.05 |
| HR estimation method | ||||||
| Directly | 3 | 624 | 1.59 (1.25, 1.93) | 0.869 | 0.0 | <0.05 |
| Indirectly | 8 | 725 | 1.64 (1.20, 1.88) | 0.994 | 0.0 | <0.05 |
Abbreviation: NOS, Newcastle–Ottawa Scale.