Table 4.
Summary of HOXD-AS1 with their potential targets, pathways, and related microRNAs
| Cancer type | Expression | Functional role | Related microRNAs | Downstream molecules | Protein binding | Signaling pathway |
|---|---|---|---|---|---|---|
|
| ||||||
| Bladder cancer | Upregulation | Cell proliferation, migration, apoptosis | / | / | / | / |
| Gastric cancer | Upregulation | Cell growth | / | p-JAK2 p-STAT3 | / | JAK/STAT pathway |
| Prostate cancer | Upregulation | Cell proliferation | / | PLK1/AURKA/FOXM1/UBE2C/CCNA2 | WDR5 | / |
| Hepatocellular carcinoma | Upregulation | Cell metastasis, apoptosis | miR-19a/miR-130a-3p | ARHGAP11A/EZH2/MMP2 | SOX4 | / |
| NSCLC | Upregulation | Cell proliferation, apoptosis, migration, invasion | miR-147a/miR-133b | / | pRB/MMP-9 | / |
| Cervical cancer | Upregulation | Cell growth | / | p-ERK1/2 | / | Ras/ERK signaling |
| Epithelial ovarian cancer | Upregulation | Cell proliferation, invasion, EMT | miR-133a-3p | E-cadherin/vimentin/β-catenin/cyclin-D1/c-myc | / | Wnt/β-catenin signaling |
| Melanoma | Upregulation | Cell proliferation, invasion | / | / | RUNX3 | / |
| Glioma | Upregulation | Migration, invasion | miR-130a | / | E2F8 | / |
| Ovarian cancer | Upregulation | Cell proliferation, migration, invasion | miR-608 | / | FZD4 | / |
| Osteosarcoma | Upregulation | Cell proliferation, migration, invasion, G0/G1 phase arrest | / | MMP-2/Bcl-2/cyclinD1/STAT3/EZH2 | P57 | / |
| Colorectal cancer | Upregulation | Cell proliferation, cell invasion, EMT and stem cell formation | miR-217 | AEG-1/EZH2 | / | / |
Notes: “/” indicates data not available.
Abbreviation: EMT, epithelial-mesenchymal transition.