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. 2018 Nov 5;11:7853–7864. doi: 10.2147/OTT.S180131

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© 2018 Wang et al. This work is published and licensed by Dove Medical Press Limited

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EZH2 was upregulated in 5-FU-resistant GC tissues and cell lines.

Notes: In (A) EZH2 expression in GC tumor (red) or normal (gray) tissues from TCGA dataset was analyzed. qRT-PCR analysis indicated the EZH2 expression levels in 36 paired GC tumor or adjacent normal tissues (B), 5-FU-sensitive or 5-FU-resistant GC tissues (C). qRT-PCR and Western blot analyses detected EZH2 mRNA and protein expression levels in 5-FU-resistant GC cell lines (AGS/5-FU and SGC-7901/5-FU) and their parental cells (AGS and SGC-7901) or human fetal gastric epithelial cell line GES-1 (D, E). (F) The overall survival was evaluated by Kaplan–Meier curve between low and high EZH2 expression groups. *P<0.05, **P<0.01, and ***P<0.001.

Abbreviations: 5-FU, 5-fluorouracil; EZH2, enhancer of zeste homologue 2; GC, gastric cancer; qRT-PCR, quantitative real-time PCR; TCGA, The Cancer Genome Atlas.