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. 2018 Nov 5;11:7853–7864. doi: 10.2147/OTT.S180131

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© 2018 Wang et al. This work is published and licensed by Dove Medical Press Limited

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EZH2 directly inhibited FBXO32 expression in GC cells.

Notes: (A) Pearson correlation coefficient analysis between EZH2 and FBXO32 in 450 tumor tissue samples of GC. (B) FBXO32 protein levels in AGS/5-FU and SGC-7901/5-FU cells transfected with si-con or si-EZH2 #1. (C, D) ChIP followed by qRT-PCR analysis was performed to evaluate the enrichment of the FBXO32 promoter on EZH2 and H3K27me3 in AGS/5-FU and SGC-7901/5-FU cells. *P<0.05.

Abbreviations: 5-FU, 5-fluorouracil; ChIP, chromatin immunoprecipitation; EZH2, enhancer of zeste homologue 2; GC, gastric cancer; qRT-PCR, quantitative real-time PCR; si-con, negative control.