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. 2018 Nov 5;11:7853–7864. doi: 10.2147/OTT.S180131

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© 2018 Wang et al. This work is published and licensed by Dove Medical Press Limited

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Overexpression of FBXO32 improved 5-FU resistance of GC cells.

Notes: (A, B) FBXO32 mRNA and protein levels were determined in 5-FU resistant AGS/5-FU and SGC-7901/5-FU cells and their parent cells. AGS/5-FU and SGC-7901/5-FU cells were transfected with Vector or FBXO32, followed by determination of FBXO32 expression by qRT-PCR and Western blot analyses (C, D), IC50 of 5-FU by MTT assay (E, F), and cell apoptotic rate by flow cytometry analysis (G, H). *P<0.05.

Abbreviations: 5-FU, 5-fluorouracil; GC, gastric cancer; IC50, half-maximal inhibitory concentration; qRT-PCR, quantitative real-time PCR; si-con, negative control.