Fig. 4.
ROS promote JNK-dependent crystal cell rupture and melanization. (A) Examples of crystal cells at 4 stages according to key. (B) Crystal cell stages 30 minutes after bleeding into 10 mM NAC, 2μM menadione, and 2μM menadione + 50μM SP600125. (C) Comparison of crystal cell expression of JNK transcriptional reporter TRE-Red after 30 mins incubation in 10 mM NAC, 2μM menadione, and 2μM menadione + 50μM SP600125. (D) Melanization (black) 40 minutes after 10 larvae each bled into 60 μM of Schneider’s media, 2 μM menadione, or 5 mM NAC. Scale bars: 10μm in (A) and 500μm in (D).