Table 2.

Univariate and multivariate analysis for clinicopathological factors of HCC patients.

Factors	OSM
	Univariate	Multivariate
	P-value	HR	95% Cl		P-value
			Lower	Upper
Age: ≤Y68 vs >Y68	0.890
Gender: male vs female	0.244
Race: White vs Asian vs Black vs others	0.428
Hepatitis/alcohol/other risk factors: yes vs no	0.073				0.927
TNM staging: I vs II vs III vs IV	<0.001	2.628	1.251	5.519	0.011
Vascular invasion: yes vs no	0.476
Tumor grade (1 vs 2 vs 3 vs 4)	0.931
AFP (µg/L): ≤20 vs >20	0.984
Platelet count (×109/L): <100 vs 100–300 vs >300	<0.001				0.816
Albumin (g/L): <35 vs 35–50 vs > 50	<0.001				0.610
Total bilirubin, mg/dL (µmol/L): ≤ 1.0 (17.1) vs >1.0 (17.1)	<0.001	2.577	1.651	4.023	<0.001
Child–Pugh classification: A vs B vs C	0.004				0.411
12-CAF marker combination: low vs high expression	0.001				0.177
11-CAF marker panel: low vs high expression	<0.001				0.619
8-Advanced CAF marker panel: low vs high expression	<0.001	2.034	1.389	2.978	<0.001
4-Early CAF marker panel: low vs high expression	0.608
3-Early CAF marker panel: low vs high expression	0.671

Note: p<0.05. Bold values indicate statistical significance.

Abbreviations: AFP, α-fetoprotein; CAFs, cancer-associated fibroblasts; OS, overall survival; HCC, hepatocellular carcinoma.