Table 1.
Composition and precompression evaluation of HHC sublingual tablet mixtures
| Formula code | F1 | F2 | F3 | F4 | F5 | F6 |
|---|---|---|---|---|---|---|
| Formula composition | ||||||
| HHC (mg) | 10 | 10 | 10 | 10 | 10 | 10 |
| SSG (%) | 3 | 5 | 7 | – | – | – |
| Pharmaburst (%) | – | – | – | 3 | 5 | 7 |
| Avicel (mg) | 80 | 80 | 80 | 80 | 80 | 80 |
| Saccharin (%) | 2 | 2 | 2 | 2 | 2 | 2 |
| Citric acid (%) | 3 | 3 | 3 | 3 | 3 | 3 |
| Talc (%) | 1 | 1 | 1 | 1 | 1 | 1 |
| d-Mannitol (mg) | 200 | 200 | 200 | 200 | 200 | 200 |
| Precompression evaluation | ||||||
| Angle of repose (°) | 33 | 34 | 33 | 30 | 30 | 29 |
| Carr’s index (%) | 20.2 | 21.1 | 20.7 | 19.8 | 20.3 | 19.9 |
| Hausner ratio | 1.21 | 1.23 | 1.19 | 1.14 | 1.16 | 1.12 |
Abbreviations: HHC, hydralazine hydrochloride; SSG, starch sod-glycolate.