Table 3.

The mean pharmacokinetic parameters of HHC after administration to rabbits by oral and sublingual routes

Pharmacokinetic parameter	OHHC	SHHC
Cmax (µg/mL)	18.0633±23.2	28.2767±4.61
Tmax (hour)	0.75±0.025	0.33±0.011
K (hour−1)	0.84±0.04	0.65±0.06
t1/2 (hour)	0.83±0.02	1.07±0.08
AUC(0–4) (µg⋅h/mL)	31.38±4.47	48.11±5.37
AUC(0–α) (µg⋅h/mL)	33.18±5.18	52.85±3.18

Abbreviations: HHC, hydralazine hydrochloride; OHHC, oral test group; SHHC, sublingual test group.