Table S1.
Univariate and multivariate analyses for OS and RFS in the validation cohort
| Characteristics | OS
|
RFS
|
||||
|---|---|---|---|---|---|---|
| Univariate P-value | Multivariate P-value | HR (95% CI) | Univariate P-value | Multivariate P-value | HR (95% CI) | |
|
| ||||||
| Gender, female/male | ||||||
| Age, <60/≥60 | 0.509 | NA | 0.176 | NA | ||
| HBsAg, negative/positive | 0.164 | NA | 0.039 | 0.006 | 2.124 (1.236–3.651) | |
| AFP, <400/≥400 ng/mL | 0.002 | NS | 0.001 | 0.019 | 1.597 (1.079–2.364) | |
| LDH, <220/≥220 U/L | 0.002 | NS | 0.008 | NS | ||
| TBIL, <20/≥20 µmol/L | 0.201 | NA | 0.131 | NA | ||
| GGT, <45/≥45 U/L | 0.045 | NS | 0.029 | NS | ||
| ALT, <50/≥50 U/L | 0.095 | NA | 0.39 | NA | ||
| ALB, <35/≥35 g/L | 0.016 | NS | 0.006 | NS | ||
| PLR, 175/≥175 | 0.001 | NS | 0.029 | NS | ||
| PNI, <45/≥45 | <0.001 | NS | 0.005 | NS | ||
| NLR, <1.65/≥1.65 | 0.011 | NS | 0.004 | NS | ||
| CRP, <10/≥10 mg/L | 0.006 | NS | 0.004 | NS | ||
| LAR, <5.5/≥5.5 | <0.001 | 0.005 | 2.145 (1.261–3.646) | <0.001 | 0.008 | 1.870 (1.173–2.982) |
| GPS, 0/1/2 | 0.002 | NS | 0.002 | NS | ||
| PI, 0/1 | 0.001 | NS | 0.007 | NS | ||
| Tumor number, single/multiple | 0.012 | 0.042 | 1.771 (1.020–3.075) | 0.012 | 0.03 | 1.706 (1.052–2.765) |
| Tumor size, <5/≥5 cm | <0.001 | 0.001 | 2.130 (1.366–3.323) | <0.001 | NS | |
| Tumor capsule, no/yes | 0.232 | NA | 0.18 | NA | ||
| Tumor thrombus, no/yes | <0.001 | 0.002 | 1.955 (1.269–3.012) | <0.001 | <0.001 | 2.200 (1.516–3.194) |
| Differentiation, | ||||||
| I–II/III–IV | 0.429 | NA | 0.21 | NA | ||
| BCLC, A/B/C | <0.001 | <0.001 | 1.781 (1.380–2.299) | <0.001 | <0.001 | 1.668 (1.342–2.073) |
| CLIP, 0/1–3/4–6 | <0.001 | <0.001 | 2.312 (1.562–3.422) | <0.001 | <0.001 | 2.545 (1.811–3.576) |
Abbreviations: ALB, albumin; AFP, alphafetal protein; BCLC, Barcelona Clinic Liver Cancer staging system; CLIP, Cancer Liver Italian Program; GGT, gamma-glutamyl transpeptidase; GPS, Glasgow Prognostic Score; LAR, lactic dehydrogenase to albumin ratio; LDH, lactic dehydrogenase; NA, non analysis; NLR, neutrophil to lymphocyte ratio; NS, non significant; OS, overall survival; PI, prognostic index; PLR, platelet to lymphocyte ratio; PNI, Prognostic Nutritional Index; RFS, recurrence-free survival; TBIL, total bilirubin.