Table S2.
Comparison of C-index in OS and RFS prediction in the validation cohort
| Variables | OS
|
RFS
|
||
|---|---|---|---|---|
| C-index | 95% CI | C-index | 95% CI | |
|
| ||||
| Combined predictive models | ||||
| Nomogram (BCLC + LAR) | 0.704 | 0.702–0.706 | 0.683 | 0.681–0.685 |
| Nomogram (CLIP + LAR) | 0.678 | 0.676–0.680 | 0.667 | 0.665–0.669 |
| Staging systems | ||||
| BCLC | 0.646 | 0.644–0.648 | 0.649 | 0.647–0.651 |
| CLIP | 0.624 | 0.622–0.626 | 0.632 | 0.630–0.634 |
| Inflammation based scores | ||||
| GPS | 0.561 | 0.559–0.563 | 0.566 | 0.564–0.568 |
| PI | 0.556 | 0.554–0.558 | 0.562 | 0.560–0.564 |
| PNI | 0.565 | 0.562–0.567 | 0.548 | 0.546–0.550 |
| NLR | 0.562 | 0.560–0.564 | 0.561 | 0.559–0.563 |
| PLR | 0.558 | 0.556–0.560 | 0.53 | 0.528–0.532 |
| CRP, <10/≥10 mg/L | 0.551 | 0.549–0.553 | 0.557 | 0.555–0.559 |
| LAR, <5.5/≥5.5 | 0.618 | 0.616–0.620 | 0.594 | 0.592–0.596 |
| Serum parameters | ||||
| GGT, <184/≥184 U/L | 0.552 | 0.550–0.554 | 0.549 | 0.547–0.551 |
| ALT, <50/≥50 U/L | 0.544 | 0.546–0.548 | 0.52 | 0.518–0.522 |
| AFP, <400/≥400 ng/mL | 0.568 | 0.566–0.570 | 0.567 | 0.565–0.568 |
| ALB, <35/≥35 g/L | 0.513 | 0.511–0.515 | 0.512 | 0.510–0.514 |
| LDH, <220/≥220 U/L | 0.559 | 0.557–0.561 | 0.549 | 0.547–0.551 |
Abbreviations: ALB, albumin; AFP, alphafetal protein; BCLC, Barcelona Clinic Liver Cancer staging system; CLIP, Cancer Liver Italian Program; GGT, gamma-glutamyl transpeptidase; GPS, Glasgow Prognostic Score; LAR, lactic dehydrogenase to albumin ratio; LDH, lactic dehydrogenase; NLR, neutrophil to lymphocyte ratio; OS, overall survival; PI, prognostic index; PLR, platelet to lymphocyte ratio; PNI, Prognostic Nutritional Index; RFS, recurrence-free survival; TBIL, total bilirubin.