Figure 2.

Autocorrelation in structural reaction coordinates at all seven sites (see Supporting Information for reaction coordinate definitions). Sites divide into three groups: L99, M106, and V149 decay rapidly; A42, M102, and F153 decay more slowly; and A98 decays very slowly. This division roughly parallels the sites requiring VB‐REX and the sites not requiring VB‐REX. At sites A42 and M102 two distances were chosen to capture the variety of structural changes observed. The autocorrelation in the distance more strongly correlated with λ is plotted; the other autocorrelation decays more rapidly in both cases.