Table 1. Body composition and metabolism during first year of Growth Hormone treatment.
| Baseline | 1-year | P value | |
|---|---|---|---|
| Anthropometry | |||
| Height SDS | -3.35 (0.74) | -2.31 (0.69) | <0.0001 |
| Weight SDS | -3.10 (1.03) | -2.12 (1.00) | <0.0001 |
| BMI (kg/m2) | 14.16 (1.49) | 14.68 (1.62) | <0.0001 |
| BMI SDS | -1.34 (1.38) | -0.96 (1.29) | <0.0001 |
| Body Composition (DXA) | |||
| Total lean mass (kg) | 11.5 (2.66) | 15.6 (3.45) | <0.0001 |
| Bone Mineral Content (g) | 457 (166) | 606 (188) | <0.0001 |
| Total body fat mass (kg) | 2.26 (1.06) | 2.06 (1.12) | 0.007 |
| Trunk fat mass (kg) | 0.68 (0.37) | 0.72 (0.41) | 0.13 |
| Limbs fat mass (kg) | 1.10 (0.68) | 1.00 (0.67) | 0.0002 |
| Total body fat (%) | 15.8 (5.80) | 11.2 (4.70) | <0.0001 |
| total body fat % (z-score)* | -0.26 (1.21) | -1.23 (1.54) | <0.0001 |
| Trunk fat (%) | 10.6 (4.66) | 8.63 (4.03) | <0.0001 |
| Limb fat (%) | 23.1 (9.70) | 14.6 (7.70) | <0.0001 |
| Trunk-limb fat ratio | 0.61 (0.20) | 0.84 (0.32) | <0.0001 |
| Biochemistry | |||
| IGF- I (SDS) | -1.09 (1.28) | 2.88 (1.52) | <0.0001 |
| Glucose (mmol/l) | 4.32 (0.66) | 4.70 (0.55) | <0.0001 |
| Insulin (pmol/l) (log) | 1.19 (0.28) | 1.59 (0.22) | <0.0001 |
| C-peptide (pmol/l) (log) | 2.30 (0.24) | 2.61 (0.17) | <0.0001 |
| Insulin sensitivity (HOMA) (log) | 2.38 (0.25) | 2.06 (0.17) | <0.0001 |
| Acute Insulin Response (log) | 3.13 (0.24) | 3.39 (0.26) | <0.0001 |
| Disposition Index (log) | 5.51 (0.24) | 5.46 (0.23) | 0.11 |
| Total Cholesterol (mmol/L) | 3.94 (0.72) | 3.88 (0.70) | 0.38 |
| LDL Cholesterol (mmol/L) | 2.23 (0.63) | 2.15 (0.58) | 0.11 |
| HDL Cholesterol (mmol/L) | 1.47 (0.35) | 1.42 (0.33) | 0.070 |
| Triglycerides (mmol/L) | 0.64 (0.33) | 0.83 (0.40) | 0.001 |
Data presented as means (SD)
*
Z-scores for percentage body fat calculated based on normative data (z-scorep)