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. Author manuscript; available in PMC: 2019 Jan 6.
Published in final edited form as: Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:663–687. doi: 10.1146/annurev-pharmtox-010617-052713

Figure 4.

Figure 4

Loss of diuretic response in Oat knockout mice. A number of SLC22 transporters have been deleted in mice, and the pharmacological and toxicological responses of knockout mice have been studied in detail. After the deletion of either (a) Oat1 or (b) Oat3—which are known to transport diuretics in vivo—the natriuretic (urine sodium excretion) response to either loop or thiazide diuretics is blunted. This is not seen in the deletion of the closely related (c) Urat1 (Rst), which is primarily a renal urate transporter. Figure adapted from References 22 and 78. Abbreviations: ED50, half-maximal effective dose; IV, intravenous; Rst, renal specific transporter; UNaV, urinary sodium excretion.