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. Author manuscript; available in PMC: 2018 Nov 9.
Published in final edited form as: Cell Rep. 2018 Oct 9;25(2):357–367.e4. doi: 10.1016/j.celrep.2018.09.039

Figure 1. Sensitive Period Remains Open at 6 Weeks for Treatment of Social and Motor Behaviors.

Figure 1.

(A) Schema for treatment paradigm.

(B) Social testing in three-chambered apparatus.

(C–F) Rapamycin initiated at 6 weeks rescues (C and D) social behaviors in three chambered apparatus, (E) social olfaction, and (F) motor function on rotarod.

(G and H) No rescue is achieved for (G) repetitive grooming nor (H) reversal learning on water T maze.

Two-way ANOVA, Bonferroni post hoc analysis. *p < 0.05, **p < 0.01, and ***p < 0.001. FA, familiar animal; NA, novel animal; NO, novel object; Ns, not significant. Rapa, rapamycin; RevDay, reversal day; VEH, vehicle. Data are reported as mean ± SEM.