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. Author manuscript; available in PMC: 2018 Nov 9.
Published in final edited form as: Cell Rep. 2018 Oct 9;25(2):357–367.e4. doi: 10.1016/j.celrep.2018.09.039

Figure 3. Brain Alterations in PC Tsc1-Mutant Mice Are Partially Rescued with Rapamycin Therapy.

Figure 3.

(A) Voxelwise differences in relative volume between control and mutant mice are partially rescued with rapamycin therapy.

(B–F) Bar plots summarizing data showing partial rescue of (B) CrusI white matter (WM), (C) CrusII WM, (D) lateral CN, (E) interposed CN, and (F) medial CN.

(G and H) Bar plots also summarize data demonstrating areas altered in PC Tsc1-mutants that are not rescued with rapamycin treatment, including anterior (Ant) lobules 4 and 5 (G) gray and (H) WM.

*FDR < 0.05; **FDR < 0.01; and ns, FDR > 0.1. CON, control; MUT, PC Tsc1 mutant; Rapa, rapamycin; VEH, vehicle. Data are reported as mean ± SEM.