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. Author manuscript; available in PMC: 2018 Nov 9.
Published in final edited form as: Cell Rep. 2018 Oct 9;25(2):357–367.e4. doi: 10.1016/j.celrep.2018.09.039

Figure 5. Electrophysiology Phenotypes with 10 Week Treatment Paradigm.

Figure 5.

Recordings were performed at 15 weeks of age (5 weeks after treatment initiation at 10 weeks of age).

(A and B) Intrinsic PC firing properties are rescued in mutants with rapamycin therapy (A), while PC excitability is not rescued in mutant mice even with rapamycin therapy (B).

Two-way ANOVA, Bonferroni post hoc analysis. **p < 0.01 and ***p < 0.001. Ns, not significant; Rapa, rapamycin; VEH, vehicle. Data are reported as mean ± SEM.