Table 1.

Impact of Treatment on Behavior and Cellular Phenotypes

	Rapa 6 Weeks	Rapa 10 Weeks
	Mutant	Het	Mutant
Social approach	rescue	rescue	no
Social novelty	rescue	rescue	no
Social olfaction	rescue	rescue	no
Grooming	no	no	no
Water T maze	no	no	no
Rotarod	rescue	no deficit	rescue
PC survival	rescue	no deficit	no

‘‘Rescue’’ denotes rescue with rapamycin treatment. ‘‘No’’ denotes lack of rescue with rapamycin treatment. ‘‘No deficit’’ indicates an absence of deficit in this model. PC, Purkinje cell; Rapa, rapamycin.