Fig. 3.
Optimization of horizontal pixel binning. (a) Simulated g1 (τd) for NPixel ranging from 512 to 1 with aSlit = 1 and NMode 1702, where total sample and reference photon numbers detected by the 512 camera pixels are set as ∼41 and ∼4.1 × 106 per 3 μs exposure, respectively. (b) RMSE of decay rates versus NPixel for NMode of 1702, 1300, 900, and 500, estimated from 20 independent sets of simulations each. (c) SANR versus NPixel estimated from simulations with digitization (open symbols) and calculated from the corresponding MMITMs (solid lines). (d) Speckle number versus NPixel estimated from simulations with digitization (open symbols) and calculated from the corresponding MMITMs (solid lines). Red dashed curves in (c) and (d) indicate theoretical SANR for binning of fully correlated pixels and theoretical speckle number for binning of uncorrelated pixels, respectively. The optimal NPixel of 64 is indicated by vertical dotted lines in (b), (c), and (d).