Mouse survival following treatment. Mice were treated with saline (control), SAuNPs alone, SAuMBs alone, SAuNPs+US, or SAuMBs+US then subjected to laser irradiation of tumors for 8 min (N = 5) and monitored for 30 d (A). Tumors were harvested to compare their sizes (B). All SAuMBs+US mice survived till the end the experiment, and no tumors were found. However, only 20% of SAuMBs only mice survived (mean tumor size: 1.3 cm), and SAuNP only mice showed 60% survival (mean tumor size: 1 cm). Interestingly, there was no substantial difference in survival between SAuNPs and SAuNPs+US groups because SAuNPs cannot induce sonoporation.